Lisdexamfetamine Products in Pakistan
⚡ Quick Overview: Lisdexamfetamine (Vyvanse & Elvanse in Pakistan)
Lisdexamfetamine Dimesylate is an advanced, long-acting central nervous system (CNS) stimulant prodrug engineered for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) in adults and children (aged 6+), as well as moderate-to-severe Binge Eating Disorder (BED). Globally known under the innovator trade names Vyvanse® (USA) and Elvanse® (UK/Europe), it is available in Pakistan through certified bio-equivalent brands including Vyas (Tekaje) and Attvanse in 30mg, 50mg, and 70mg strengths.
How Lisdexamfetamine Works: The Prodrug Advantage
Unlike traditional immediate-release stimulants (such as Methylphenidate / Ritalin or immediate Dextroamphetamine) that cause sharp plasma concentration spikes and subsequent afternoon crashes, Lisdexamfetamine is pharmacologically inactive in its administered form.
Following oral ingestion and gastrointestinal absorption, Lisdexamfetamine is transported to the bloodstream where red blood cells (erythrocytes) enzymatically hydrolyze the molecule, cleaving L-lysine amino acid to gradually release active d-amphetamine. This rate-limited enzymatic bio-activation yields:
- Consistent 12 to 14-Hour Cognitive Focus: Provides smooth, steady dopamine and norepinephrine transmission throughout work or academic hours.
- No Abrupt Evening Crashes: Eliminates the severe rebound irritability, anxiety, or exhaustion common with instant-release stimulants.
- Abuse-Deterrent Pharmacokinetics: Because conversion requires red blood cell enzymes in the bloodstream, the prodrug cannot be accelerated via non-oral routes.
Comparison: Lisdexamfetamine Brands & Formulations in Pakistan
| Brand Name | Manufacturer | Available Strengths | Duration of Action | Price & Availability in Pakistan |
|---|---|---|---|---|
| Vyas (30mg, 50mg, 70mg) | Tekaje (Iran / Middle East) | 30mg, 50mg, 70mg Capsules | 12–14 Hours | PKR 12,800 – 19,250 (Ready Stock) |
| Attvanse (30mg, 50mg, 70mg) | Certified Pharmaceutical GMP | 30mg, 50mg, 70mg Capsules | 12–14 Hours | PKR 13,500 – 19,500 (Authentic Import) |
| Vyvanse® (Innovator) | Takeda Pharmaceuticals (USA) | 10mg to 70mg | 12–14 Hours | PKR 35,000+ (High Import Markup / Shortages) |
| Elvanse® (Innovator) | Takeda (UK / Europe) | 20mg to 70mg | 12–14 Hours | Premium European Import Cost |
đź“‹ Lisdexamfetamine Products & Price List in Pakistan (2026)
| Product Name | Brand | Origin | Quality | Pack Size | Price in Pakistan (PKR) |
|---|---|---|---|---|---|
| VYAS 30 mg | Tekaje | Iran | 100% Original | 30 capsule | Rs 12,800As low as Rs 11,800 |
| Attvanse 30mg | Faran Shimi | Iran | 100% Original | 30 capsule | Rs 14,800As low as Rs 13,960 |
| VYAS 50 mg | Tekaje | Iran | 100% Original | 30 capsule | Rs 17,200As low as Rs 15,700 |
| VYAS 70 mg | Tekaje | Iran | 100% Original | 30 capsule | Rs 19,250As low as Rs 17,800 |
| Attvanse 50mg | Faran Shimi | Iran | 100% Original | 30 capsule | Rs 19,250As low as Rs 18,200 |
| Attvanse 70mg | Faran Shimi | Iran | 100% Original | 30 capsule | Rs 22,000As low as Rs 20,800 |
Available
Rs: 12,800
As low asRs 11,800
Available
Rs: 14,800
As low asRs 13,960
Available
Rs: 17,200
As low asRs 15,700
Available
Rs: 19,250
As low asRs 17,800
Available
Rs: 19,250
As low asRs 18,200
Available
Rs: 22,000
As low asRs 20,800
Frequently Asked Questions about Lisdexamfetamine Formulations
Clinical Dosage Titration & Administration Guide
- Standard Initial Dosage: 30mg taken once daily in the morning with or without food.
- Dosage Titration: If clinically indicated, physicians may titrate dosage in 10mg to 20mg increments at weekly intervals up to a maximum recommended dose of 70mg/day.
- Administration Options: Capsules should be swallowed whole with water. Alternatively, the capsule may be opened and the entire contents dissolved into water, orange juice, or yogurt for immediate ingestion.
- Morning Intake: Due to the 12–14 hour therapeutic duration, avoid afternoon or evening doses to prevent insomnia.